The albumin-bilirubin grade improves hepatic reserve estimation post-sorafenib failure: implications for drug development
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چکیده
منابع مشابه
Influence of albumin on the hepatic uptake of unconjugated bilirubin.
1. The initial distiibution volumes of [3H]bilirubin in six adult subjects were equivalent to those of "I-labelled albumin following simultaneous intravenous injection of both compounds. However, the initial rate of loss of [3H]bilirubin from plasma was seven to thirty times faster than that of 1311-labelled albumin. 2. In vitro uptake of [3H]bilirubin by Gunn rat liver slices occurred at a rat...
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The selection of treatment options for hepatocellular carcinoma (HCC) requires critical consideration of hepatic functional reserve in addition to tumor burden (e.g., size and number of HCC nodules [tumor node metastasis stage]). Presently, the Child-Pugh classification is the most common worldwide measure used to assess hepatic functional reserve for the selection of treatment options for HCC ...
متن کاملBeneficial Effect of Maintaining Hepatic Reserve during Chemotherapy on the Outcomes of Patients with Hepatocellular Carcinoma.
Hepatocellular carcinoma (HCC) usually develops in chronically damaged liver. We investigated hepatic reserves during chemotherapy of patients with advanced HCC and compensated liver function to evaluate the effect on patients' outcomes of maintaining hepatic reserve after chemotherapy. We retrospectively reviewed the medical records of 190 patients with Child-Pugh A with advanced HCC who were ...
متن کاملAlbumin-bilirubin binding mechanism.
After binding of bilirubin to human serum albumin (1:1), a train of relaxational changes of conformation takes place. The late part of these processes, occurring in the time interval 1-500 s, has been studied by recording the changes of light absorption. Similar processes have been demonstrated after binding of fatty acid anion to the bilirubin-albumin complex as well as after a pH-jump from 6 ...
متن کاملBilirubin/Albumin Ratio for Predicting Acute Bilirubin-induced Neurologic Dysfunction
OBJECTIVE The aim of this study was to evaluate the bilirubin albumin (B/A) ratio in comparison with total serum bilirubin (TSB) for predicting acute bilirubin-induced neurologic dysfunction (BIND). METHODS Fifty two term and near term neonates requiring phototherapy and exchange transfusion for severe hyperbilirubinemia in Children's Medical Center, Tehran, Iran, during September 2007 to Sep...
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ژورنال
عنوان ژورنال: Alimentary Pharmacology & Therapeutics
سال: 2017
ISSN: 0269-2813
DOI: 10.1111/apt.13904